Vitamin D And Hypothyroidism Samples †MyAssignmenthelp.com

Question: Discuss about the Vitamin D And Hypothyroidism. Answer: The assignment deals with the discussion on the topic vitamin D and hypothyroidism supporting with the different relevant research articles. As per the literature review, vitamin D inadequacy is associated with autoimmune disease. This vitamin plays a key role in maintaining the balance between cell mediated (Th1) and the humoral (Th2) immune system by regulating the Th3 cells. In an experimental study, vitamin D deficiency resulted in low thyroid hormones. It means the vitamin has direct impact on the thyroid gland[1]. According to the genetic studies both the thyroid hormone and the vitamin D bind to the same steroid hormone receptors. This results in the autoimmune diseases, where a different gene in Vitamin D receptor has been found to predispose patients to Hashimotos thyroiditis and Graves disease. Graves disease is associated with the polymorphism in the vitamin D gene. Its deficiency directly modulates the Graves hyperthyroidism which may have been induced by the thyrotropin receptor immunization in a mice model. In the human mole it was found that the inflammatory responses in T cells and human thyroid cells was inhibited by the Vitamin D analog[2]. Many researchers studied the impact of the vitamin D on the thyroid physiology. It was found that the autoimmune thyroid disease is linked to vitamin D deficiency. This vitamin is found to benefit the autoimmune-mediated thyroid dysfunction. The vitamin is found with little role in the regulation of insulin secretion and insulin resistance. Vitamin D is also associated with the balancing of blood sugar. Thyroid physiology is adversely effected with the dysglyemcia and insulin resistance[3]. Mackawy et al, examined the relationship between vitamin D deficiency and hypothyroidism. The study results showed that the patients diagnosed with hypothyroidism were found to have vitamin D deficiency and hypocalcaemia. These deficiencies were in turn associated with the severity and degree of hypothyroidism. In short, these results showed the linkage of hypothyroidism in patients with calcium and vitamin D levels. When compared to the controls the serum levels of both the elements were found to lower in hypothyroid patients that signifies a positive association between hypothyroidism and vitamin D as well as calcium. However, there was a negative correlation of these factors with the TSH levels[4]. Singh et al., in similar study emphasised on the imunomodulatory role of the vitamin D on the endocrine system. In this study 40 healthy people and 40 hypothyroidism patients were recruited for measuring the Serum vitamin D (25-OH) levels and Thyroid hormones (TSH, T3 and T4) levels. The results using the ELISA and spectophotometric method, it was found that the level of each of them was significantly lower in the hypothyroid patientswhen compared to the healthy subjects. There was difference of these levels between males and females with later showing lower levels of these factors. These results indicated that the hypothyroid patients suffered from the hypovitaminosis D. The hypovitaminosis D iss significantly associated with degree and severity of the hypothyroidism[5]. Hypothyroid patients with vitamin D showed improvement in the condition by taking Vitamin D as it caused TSH suppression[6]. In conclusion, the literature review indicates the association between vitamin D deficiency and hyperthyroidism. As per these findings, the patients with hypothyroidism should be advocated for vitamin D supplementation. Bibliography Mackawy, Amal Mohammed Husein, Bushra Mohammed Al-Ayed, and Bashayer Mater Al-Rashidi. "Vitamin d deficiency and its association with thyroid disease."International journal of health sciences7.3 (2013): 267. Musa, I. R., Gasim, G. I., Khan, S., Ibrahim, I. A., Abo-alazm, H., Adam, I. (2017). No Association between 25 (OH) Vitamin D Level And Hypothyroidism among Females. Open Access Maced J Med Sci. 2017 Apr 15; 5 (2): 126-130. Singh, Vivek, Sunita Singh, and Yogesh Kumar Rai. "Vitamin D Induced Hypothyroidism."Indian Journal of Public Health Research Development7.3 (2016). Talaei, Afsaneh, et al. "The Study the Effect of Vitamin D on Hypothyroidism."ISMJ20.3 (2017): 301-307. Yasuda, Tetsuyuki, et al. "Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves disease."Endocrine42.3 (2012): 739-741.